Duke Nukem: Land of the Babes is a third-person shooter video game developed by n-Space and published by Infogrames. It is a spin-off of 3D Realms' Duke Nukem series of video games.

Duke is relaxing at a strip club when suddenly a portal opens and a woman appears to give Duke his (old) sunglasses, but pigcops follow her and kill her. After killing the pigcops Duke heads through the portal which leads him to an underground bunker in the future. There, a woman named Jane explains to him that the aliens have exterminated all men on earth and the women are captured to be used as slaves and that Silverback (a pigcop, ape hybrid) is leading the assault on UBR (unified babe resistance).

The first levels consist of escaping the underground bunker and shooting down Silverback's ship with the purpose of rescuing a UBR scientist named Houston who was taken to the ship, but the ship crashes in the sunken city ruins. In the following levels Jane sets up Duke with scuba gear to go in after the ship and saving Houston but he only finds one of the captured women without Houston. After the underwater levels Duke finds a hidden entrance into Silverback's base which is in a sewer, and eventually fights Silverback, who uses an armored robotic suit.

After killing Silverback, Duke goes through a portal which leads him to an alien mine and eventually into a factory where the aliens are creating killer robots which are identical to the UBR women. At one point Duke reaches a junkyard where he destroys the main computer that handles the robots and afterwards steals a spacesuit and ship which he uses to get to an alien space station. It is here where Duke finally rescues Houston who tells him that due to his success against the alien captain Silverback, they are planning to use the space station to blow up the earth. After rescuing all the women imprisoned in the space station Duke reaches "the gauntlet" where the alien leader challenges him to conquer all its levels in order to fight him, in the gauntlet Duke fights all enemy types he has faced throughout the game (except the aquatic ones), then finally he fights the alien boss which is like a larger version of the green cyclops soldiers with a hovercraft. In the ending sequence the UBR is running the "operation repopulation" which involves Duke (being the only living male) singlehandedly repopulating the planet.