Mario vs. Donkey Kong is a 2004 puzzle-platform game developed by Nintendo Software Technology and published by Nintendo for the Game Boy Advance. The game is the spiritual successor to Donkey Kong, which was released in 1994 for the Game Boy.

The gameplay revolves around a combination of platform and puzzle elements. Players control Mario through small sets of challenge to find a key and rescue Mini-Marios from Donkey Kong.

Mario vs. Donkey Kong received positive reviews, particularly for its gameplay and graphics. It spawned a franchise of the same name with the first sequel, Mario vs. Donkey Kong 2: March of the Minis, was released on Nintendo DS in September 2006. A remake for the Nintendo Switch was released in February 2024.